208391

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2208837..2209354 Replicon chromosome
Accession NZ_CP077885
Organism Staphylococcus aureus strain 355

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KU507_RS11395 Protein ID WP_000113262.1
Coordinates 2208837..2209103 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU507_RS11400 Protein ID WP_000584499.1
Coordinates 2209103..2209354 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU507_RS11365 (2204263) 2204263..2204799 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
KU507_RS11370 (2205032) 2205032..2205856 - 825 WP_000572040.1 formate/nitrite transporter family protein -
KU507_RS11375 (2206073) 2206073..2206255 - 183 WP_000230294.1 hypothetical protein -
KU507_RS11380 (2206339) 2206339..2206806 - 468 WP_000153344.1 SRPBCC domain-containing protein -
KU507_RS11385 (2206992) 2206992..2208542 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU507_RS11390 (2208731) 2208731..2208802 - 72 Protein_2201 hypothetical protein -
KU507_RS11395 (2208837) 2208837..2209103 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KU507_RS11400 (2209103) 2209103..2209354 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU507_RS11405 (2209519) 2209519..2209620 - 102 WP_001791744.1 hypothetical protein -
KU507_RS11410 (2209627) 2209627..2210226 - 600 WP_000162813.1 DsbA family protein -
KU507_RS11415 (2210245) 2210245..2210607 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KU507_RS11420 (2210862) 2210862..2212112 + 1251 WP_225806110.1 FemA/FemB family glycyltransferase FmhA -
KU507_RS11425 (2212209) 2212209..2212940 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU507_RS11430 (2212937) 2212937..2213656 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T208391 WP_000113262.1 NZ_CP077885:c2209103-2208837 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208391 NZ_CP103633:2923180-2923287 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208391 WP_000584499.1 NZ_CP077885:c2209354-2209103 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208391 NZ_CP103633:c2923127-2923066 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References