Detailed information of TA system TA208385

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1604098..1604280
• Replicon: chromosome
• Accession: NZ_CP077885
• Organism: Staphylococcus aureus strain 355

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU507_RS08055
• Protein ID: WP_001801861.1
• Coordinates: 1604098..1604193 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1604221..1604280 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU507_RS08015	1599757..1600383	+	627	WP_000669046.1	hypothetical protein	-
KU507_RS08020	1600424..1600768	+	345	WP_000627551.1	DUF3969 family protein	-
KU507_RS08025	1600866..1601417	+	552	WP_000414205.1	hypothetical protein	-
KU507_RS08030	1601635..1602276	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
KU507_RS08035	1602391..1602576	-	186	WP_000809857.1	hypothetical protein	-
KU507_RS08040	1602578..1602754	-	177	WP_000375476.1	hypothetical protein	-
KU507_RS08045	1602765..1603148	-	384	WP_000070812.1	hypothetical protein	-
KU507_RS08050	1603752..1603895	-	144	WP_001549059.1	transposase	-
KU507_RS08055	1604098..1604193	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1604221..1604280	-	60	-	-	Antitoxin
KU507_RS08060	1604316..1604417	+	102	WP_001791893.1	hypothetical protein	-
KU507_RS08065	1604395..1604571	-	177	Protein_1587	transposase	-
KU507_RS08070	1604765..1605142	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1578071..1679825	101754

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208385 WP_001801861.1 NZ_CP077885:1604098-1604193 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208385 NZ_CP103633:1986170-1986421 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT208385 NZ_CP077885:c1604280-1604221 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin