Detailed information of TA system TA208382

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 632025..632363
• Replicon: chromosome
• Accession: NZ_CP077885
• Organism: Staphylococcus aureus strain 355

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU507_RS03415
• Protein ID: WP_011447039.1
• Coordinates: 632025..632201 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	632189..632363 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU507_RS03395	629855..630007	+	153	WP_001000058.1	hypothetical protein	-
KU507_RS03400	630053..630340	+	288	WP_001262621.1	hypothetical protein	-
KU507_RS03405	630396..630770	+	375	WP_000340977.1	hypothetical protein	-
KU507_RS03410	631143..631916	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
KU507_RS03415	632025..632201	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	632189..632363	-	175	-	-	Antitoxin
KU507_RS03425	632413..632667	+	255	WP_000611512.1	phage holin	-
KU507_RS03430	632679..633434	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU507_RS03435	633625..634116	+	492	WP_000920038.1	staphylokinase	-
KU507_RS03440	634767..635102	+	336	Protein_666	SH3 domain-containing protein	-
KU507_RS03445	635347..635499	+	153	WP_001788502.1	hypothetical protein	-
KU507_RS03450	635570..635680	+	111	WP_000139423.1	hypothetical protein	-
KU507_RS03455	635682..635867	+	186	WP_001286805.1	hypothetical protein	-
KU507_RS03460	636503..637060	+	558	WP_000528632.1	PBECR4 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208382 WP_011447039.1 NZ_CP077885:632025-632201 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208382 NZ_CP103633:1098302-1098637 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT208382 NZ_CP077885:c632363-632189 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin