Detailed information of TA system TA208375

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 675770..675952
• Replicon: chromosome
• Accession: NZ_CP077880
• Organism: Staphylococcus aureus strain 356

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU497_RS03695
• Protein ID: WP_001801861.1
• Coordinates: 675857..675952 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	675770..675829 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU497_RS03680	674908..675285	+	378	WP_001037045.1	DUF1433 domain-containing protein	-
KU497_RS03685	675479..675655	+	177	Protein_685	transposase	-
KU497_RS03690	675633..675734	-	102	WP_001791893.1	hypothetical protein	-
-	675770..675829	+	60	-	-	Antitoxin
KU497_RS03695	675857..675952	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
KU497_RS03700	676155..676298	+	144	WP_001549059.1	transposase	-
KU497_RS03705	676902..677285	+	384	WP_000070812.1	hypothetical protein	-
KU497_RS03710	677296..677472	+	177	WP_000375476.1	hypothetical protein	-
KU497_RS03715	677474..677659	+	186	WP_000809857.1	hypothetical protein	-
KU497_RS03720	677774..678415	+	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
KU497_RS03725	678633..679184	-	552	WP_000414205.1	hypothetical protein	-
KU497_RS03730	679282..679626	-	345	WP_000627551.1	DUF3969 family protein	-
KU497_RS03735	679667..680293	-	627	WP_000669046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208375 WP_001801861.1 NZ_CP077880:c675952-675857 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208375 NZ_CP103633:220727-220834 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT208375 NZ_CP077880:675770-675829 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin