Detailed information of TA system TA208368

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 336017..336280
• Replicon: chromosome
• Accession: NZ_CP077880
• Organism: Staphylococcus aureus strain 356

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU497_RS01740
• Protein ID: WP_001802298.1
• Coordinates: 336017..336121 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	336116..336280 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU497_RS01710	331401..332183	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
KU497_RS01715	332251..333108	+	858	WP_000370924.1	HAD family hydrolase	-
KU497_RS01720	333340..333524	-	185	Protein_335	exotoxin	-
KU497_RS01725	333813..333905	-	93	WP_001790138.1	hypothetical protein	-
KU497_RS01730	334194..335330	+	1137	WP_000115562.1	SAP domain-containing protein	-
KU497_RS01735	335373..335856	+	484	Protein_338	recombinase family protein	-
KU497_RS01740	336017..336121	+	105	WP_001802298.1	hypothetical protein	Toxin
-	336116..336280	-	165	-	-	Antitoxin
KU497_RS01750	336621..337712	-	1092	WP_000495671.1	lytic regulatory protein	-
KU497_RS01755	337978..338958	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU497_RS01760	338960..339280	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU497_RS01765	339432..340097	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208368 WP_001802298.1 NZ_CP077880:336017-336121 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208368 NZ_CP103626:3529321-3529539 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT208368 NZ_CP077880:c336280-336116 [Staphylococcus aureus]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin