Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 70693..71210 Replicon chromosome
Accession NZ_CP077880
Organism Staphylococcus aureus strain 356

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KU497_RS00355 Protein ID WP_000113262.1
Coordinates 70944..71210 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU497_RS00350 Protein ID WP_000584499.1
Coordinates 70693..70944 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU497_RS00320 (66391) 66391..67110 + 720 WP_000479576.1 amino acid ABC transporter permease -
KU497_RS00325 (67107) 67107..67838 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU497_RS00330 (67935) 67935..69185 - 1251 WP_225806110.1 FemA/FemB family glycyltransferase FmhA -
KU497_RS00335 (69440) 69440..69802 + 363 WP_000819843.1 DUF4467 domain-containing protein -
KU497_RS00340 (69821) 69821..70420 + 600 WP_000162813.1 DsbA family protein -
KU497_RS00345 (70427) 70427..70528 + 102 WP_001791744.1 hypothetical protein -
KU497_RS00350 (70693) 70693..70944 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU497_RS00355 (70944) 70944..71210 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KU497_RS00360 (71245) 71245..71316 + 72 Protein_71 hypothetical protein -
KU497_RS00365 (71505) 71505..73055 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU497_RS00370 (73241) 73241..73708 + 468 WP_000153344.1 SRPBCC domain-containing protein -
KU497_RS00375 (73792) 73792..73974 + 183 WP_000230294.1 hypothetical protein -
KU497_RS00380 (74191) 74191..75015 + 825 WP_000572040.1 formate/nitrite transporter family protein -
KU497_RS00385 (75248) 75248..75784 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T208367 WP_000113262.1 NZ_CP077880:70944-71210 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208367 NZ_CP103626:2776997-2777104 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208367 WP_000584499.1 NZ_CP077880:70693-70944 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208367 NZ_CP103626:c2776944-2776883 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References