Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 13961..14484 Replicon chromosome
Accession NZ_CP077880
Organism Staphylococcus aureus strain 356

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag KU497_RS00080 Protein ID WP_000074048.1
Coordinates 14218..14484 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KU497_RS00075 Protein ID WP_000587616.1
Coordinates 13961..14218 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU497_RS00050 (9041) 9041..10234 + 1194 WP_000675401.1 MFS transporter -
KU497_RS00055 (10458) 10458..11207 - 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
KU497_RS00060 (11402) 11402..12979 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
KU497_RS00065 (13147) 13147..13602 - 456 WP_000732082.1 DUF1307 domain-containing protein -
KU497_RS00070 (13661) 13661..13855 + 195 WP_001790145.1 hypothetical protein -
KU497_RS00075 (13961) 13961..14218 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU497_RS00080 (14218) 14218..14484 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
KU497_RS00085 (14839) 14839..15915 + 1077 WP_001076671.1 M42 family metallopeptidase -
KU497_RS00090 (16162) 16162..16824 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
KU497_RS00095 (16817) 16817..17593 + 777 WP_050956485.1 iron export ABC transporter permease subunit FetB -
KU497_RS00100 (17989) 17989..19176 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T208364 WP_000074048.1 NZ_CP077880:14218-14484 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T208364 NZ_CP103626:2101678-2101781 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGGCCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT208364 WP_000587616.1 NZ_CP077880:13961-14218 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208364 NZ_CP103626:c2101819-2101548 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGCCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References