Detailed information of TA system TA208361

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2744184..2744366
• Replicon: chromosome
• Accession: NZ_CP077877
• Organism: Staphylococcus aureus strain 357

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU522_RS13550
• Protein ID: WP_001801861.1
• Coordinates: 2744184..2744279 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2744307..2744366 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU522_RS13510	2739843..2740469	+	627	WP_000669046.1	hypothetical protein	-
KU522_RS13515	2740510..2740854	+	345	WP_000627551.1	DUF3969 family protein	-
KU522_RS13520	2740952..2741503	+	552	WP_000414205.1	hypothetical protein	-
KU522_RS13525	2741721..2742362	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
KU522_RS13530	2742477..2742662	-	186	WP_000809857.1	hypothetical protein	-
KU522_RS13535	2742664..2742840	-	177	WP_000375476.1	hypothetical protein	-
KU522_RS13540	2742851..2743234	-	384	WP_000070812.1	hypothetical protein	-
KU522_RS13545	2743838..2743981	-	144	WP_001549059.1	transposase	-
KU522_RS13550	2744184..2744279	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2744307..2744366	-	60	-	-	Antitoxin
KU522_RS13555	2744402..2744503	+	102	WP_001791893.1	hypothetical protein	-
KU522_RS13560	2744481..2744657	-	177	Protein_2667	transposase	-
KU522_RS13565	2744851..2745228	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208361 WP_001801861.1 NZ_CP077877:2744184-2744279 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208361 NZ_CP103626:1362934-1363332 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT208361 NZ_CP077877:c2744366-2744307 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin