Detailed information of TA system TA208358

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1772111..1772449
• Replicon: chromosome
• Accession: NZ_CP077877
• Organism: Staphylococcus aureus strain 357

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU522_RS08910
• Protein ID: WP_011447039.1
• Coordinates: 1772111..1772287 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1772275..1772449 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU522_RS08890	1769941..1770093	+	153	WP_001000058.1	hypothetical protein	-
KU522_RS08895	1770139..1770426	+	288	WP_001262621.1	hypothetical protein	-
KU522_RS08900	1770482..1770856	+	375	WP_000340977.1	hypothetical protein	-
KU522_RS08905	1771229..1772002	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
KU522_RS08910	1772111..1772287	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1772275..1772449	-	175	-	-	Antitoxin
KU522_RS08920	1772499..1772753	+	255	WP_000611512.1	phage holin	-
KU522_RS08925	1772765..1773520	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU522_RS08930	1773711..1774202	+	492	WP_000920038.1	staphylokinase	-
KU522_RS08935	1774853..1775188	+	336	Protein_1746	SH3 domain-containing protein	-
KU522_RS08940	1775433..1775585	+	153	WP_001788502.1	hypothetical protein	-
KU522_RS08945	1775656..1775766	+	111	WP_000139423.1	hypothetical protein	-
KU522_RS08950	1775768..1775953	+	186	WP_001286805.1	hypothetical protein	-
KU522_RS08955	1776589..1777146	+	558	WP_000528632.1	PBECR4 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208358 WP_011447039.1 NZ_CP077877:1772111-1772287 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208358 NZ_CP103626:871512-871919 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT208358 NZ_CP077877:c1772449-1772275 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin