Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 518800..518984 Replicon chromosome
Accession NZ_CP077877
Organism Staphylococcus aureus strain 357

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag KU522_RS02685 Protein ID WP_000482650.1
Coordinates 518877..518984 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 518800..518860 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU522_RS02670 514330..514497 - 168 WP_001790576.1 hypothetical protein -
KU522_RS02675 514728..516461 - 1734 WP_031833708.1 ABC transporter ATP-binding protein -
KU522_RS02680 516486..518249 - 1764 WP_001064838.1 ABC transporter ATP-binding protein -
- 518800..518860 + 61 - - Antitoxin
KU522_RS02685 518877..518984 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
KU522_RS02690 519117..519503 - 387 WP_000779358.1 flippase GtxA -
KU522_RS02695 519771..520913 + 1143 WP_001176863.1 glycerate kinase -
KU522_RS02700 520973..521632 + 660 WP_000831298.1 membrane protein -
KU522_RS02705 521814..523025 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
KU522_RS02710 523148..523621 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T208354 WP_000482650.1 NZ_CP077877:c518984-518877 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208354 NZ_CP103626:263362-263592 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 61 bp

>AT208354 NZ_CP077877:518800-518860 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References