Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 493571..494088 Replicon chromosome
Accession NZ_CP077877
Organism Staphylococcus aureus strain 357

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KU522_RS02550 Protein ID WP_000113262.1
Coordinates 493571..493837 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU522_RS02555 Protein ID WP_000584499.1
Coordinates 493837..494088 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU522_RS02520 (488997) 488997..489533 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
KU522_RS02525 (489766) 489766..490590 - 825 WP_000572040.1 formate/nitrite transporter family protein -
KU522_RS02530 (490807) 490807..490989 - 183 WP_000230294.1 hypothetical protein -
KU522_RS02535 (491073) 491073..491540 - 468 WP_000153344.1 SRPBCC domain-containing protein -
KU522_RS02540 (491726) 491726..493276 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU522_RS02545 (493465) 493465..493536 - 72 Protein_491 hypothetical protein -
KU522_RS02550 (493571) 493571..493837 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KU522_RS02555 (493837) 493837..494088 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU522_RS02560 (494253) 494253..494354 - 102 WP_001791744.1 hypothetical protein -
KU522_RS02565 (494361) 494361..494960 - 600 WP_000162813.1 DsbA family protein -
KU522_RS02570 (494979) 494979..495341 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KU522_RS02575 (495596) 495596..496846 + 1251 WP_225806110.1 FemA/FemB family glycyltransferase FmhA -
KU522_RS02580 (496943) 496943..497674 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU522_RS02585 (497671) 497671..498390 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T208353 WP_000113262.1 NZ_CP077877:c493837-493571 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208353 NZ_CP103624:76992-77267 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208353 WP_000584499.1 NZ_CP077877:c494088-493837 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208353 NZ_CP103624:76708-76992 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCTCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References