Detailed information of TA system TA208352

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 228547..228764
• Replicon: chromosome
• Accession: NZ_CP077877
• Organism: Staphylococcus aureus strain 357

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU522_RS01165
• Protein ID: WP_001802298.1
• Coordinates: 228660..228764 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	228547..228602 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU522_RS01140	224684..225349	-	666	WP_001024094.1	SDR family oxidoreductase	-
KU522_RS01145	225501..225821	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU522_RS01150	225823..226803	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU522_RS01155	227069..228160	+	1092	WP_000495671.1	lytic regulatory protein	-
-	228547..228602	+	56	-	-	Antitoxin
KU522_RS01165	228660..228764	-	105	WP_001802298.1	hypothetical protein	Toxin
KU522_RS01170	228925..229408	-	484	Protein_224	recombinase family protein	-
KU522_RS01175	229451..230587	-	1137	WP_000115562.1	SAP domain-containing protein	-
KU522_RS01180	230876..230968	+	93	WP_001790138.1	hypothetical protein	-
KU522_RS01185	231257..231441	+	185	Protein_227	exotoxin	-
KU522_RS01190	231673..232530	-	858	WP_000370924.1	HAD family hydrolase	-
KU522_RS01195	232598..233380	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208352 WP_001802298.1 NZ_CP077877:c228764-228660 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208352 NZ_CP103623:c4633730-4633419 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208352 NZ_CP077877:228547-228602 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin