Detailed information of TA system TA208345

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2781001..2781264
• Replicon: chromosome
• Accession: NZ_CP077872
• Organism: Staphylococcus aureus strain 358

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU513_RS13965
• Protein ID: WP_001802298.1
• Coordinates: 2781001..2781105 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2781100..2781264 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU513_RS13935	2776385..2777167	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
KU513_RS13940	2777235..2778092	+	858	WP_000370924.1	HAD family hydrolase	-
KU513_RS13945	2778324..2778508	-	185	Protein_2711	exotoxin	-
KU513_RS13950	2778797..2778889	-	93	WP_001790138.1	hypothetical protein	-
KU513_RS13955	2779178..2780314	+	1137	WP_000115562.1	SAP domain-containing protein	-
KU513_RS13960	2780357..2780840	+	484	Protein_2714	recombinase family protein	-
KU513_RS13965	2781001..2781105	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2781100..2781264	-	165	-	-	Antitoxin
KU513_RS13975	2781605..2782696	-	1092	WP_000495671.1	lytic regulatory protein	-
KU513_RS13980	2782962..2783942	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU513_RS13985	2783944..2784264	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU513_RS13990	2784416..2785081	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208345 WP_001802298.1 NZ_CP077872:2781001-2781105 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208345 NZ_CP103623:3453456-3453674 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT208345 NZ_CP077872:c2781264-2781100 [Staphylococcus aureus]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin