Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2515677..2516194 Replicon chromosome
Accession NZ_CP077872
Organism Staphylococcus aureus strain 358

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KU513_RS12580 Protein ID WP_000113262.1
Coordinates 2515928..2516194 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU513_RS12575 Protein ID WP_000584499.1
Coordinates 2515677..2515928 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU513_RS12545 (2511375) 2511375..2512094 + 720 WP_000479576.1 amino acid ABC transporter permease -
KU513_RS12550 (2512091) 2512091..2512822 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU513_RS12555 (2512919) 2512919..2514169 - 1251 WP_225806110.1 FemA/FemB family glycyltransferase FmhA -
KU513_RS12560 (2514424) 2514424..2514786 + 363 WP_000819843.1 DUF4467 domain-containing protein -
KU513_RS12565 (2514805) 2514805..2515404 + 600 WP_000162813.1 DsbA family protein -
KU513_RS12570 (2515411) 2515411..2515512 + 102 WP_001791744.1 hypothetical protein -
KU513_RS12575 (2515677) 2515677..2515928 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU513_RS12580 (2515928) 2515928..2516194 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KU513_RS12585 (2516229) 2516229..2516300 + 72 Protein_2447 hypothetical protein -
KU513_RS12590 (2516489) 2516489..2518039 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU513_RS12595 (2518225) 2518225..2518692 + 468 WP_000153344.1 SRPBCC domain-containing protein -
KU513_RS12600 (2518776) 2518776..2518958 + 183 WP_000230294.1 hypothetical protein -
KU513_RS12605 (2519175) 2519175..2519999 + 825 WP_000572040.1 formate/nitrite transporter family protein -
KU513_RS12610 (2520232) 2520232..2520768 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T208344 WP_000113262.1 NZ_CP077872:2515928-2516194 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208344 NZ_CP103623:2691724-2691831 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208344 WP_000584499.1 NZ_CP077872:2515677-2515928 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208344 NZ_CP103623:c2691674-2691611 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References