Detailed information of TA system TA208342

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2490781..2490965
• Replicon: chromosome
• Accession: NZ_CP077872
• Organism: Staphylococcus aureus strain 358

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: KU513_RS12445
• Protein ID: WP_000482650.1
• Coordinates: 2490781..2490888 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2490905..2490965 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU513_RS12420	2486144..2486617	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
KU513_RS12425	2486740..2487951	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU513_RS12430	2488133..2488792	-	660	WP_000831298.1	membrane protein	-
KU513_RS12435	2488852..2489994	-	1143	WP_001176863.1	glycerate kinase	-
KU513_RS12440	2490262..2490648	+	387	WP_000779358.1	flippase GtxA	-
KU513_RS12445	2490781..2490888	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2490905..2490965	-	61	-	-	Antitoxin
KU513_RS12450	2491516..2493279	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
KU513_RS12455	2493304..2495037	+	1734	WP_031833708.1	ABC transporter ATP-binding protein	-
KU513_RS12460	2495268..2495435	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208342 WP_000482650.1 NZ_CP077872:2490781-2490888 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208342 NZ_CP103623:2690653-2690760 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208342 NZ_CP077872:c2490965-2490905 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin