208341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2458945..2459468 Replicon chromosome
Accession NZ_CP077872
Organism Staphylococcus aureus strain 358

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag KU513_RS12305 Protein ID WP_000074048.1
Coordinates 2459202..2459468 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KU513_RS12300 Protein ID WP_000587616.1
Coordinates 2458945..2459202 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU513_RS12280 (2454025) 2454025..2455218 + 1194 WP_000675401.1 MFS transporter -
KU513_RS12285 (2455442) 2455442..2456191 - 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
KU513_RS12290 (2456386) 2456386..2457963 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
KU513_RS12295 (2458131) 2458131..2458586 - 456 WP_000732082.1 DUF1307 domain-containing protein -
KU513_RS12300 (2458945) 2458945..2459202 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU513_RS12305 (2459202) 2459202..2459468 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
KU513_RS12310 (2459823) 2459823..2460899 + 1077 WP_001076671.1 M42 family metallopeptidase -
KU513_RS12315 (2461146) 2461146..2461808 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
KU513_RS12320 (2461801) 2461801..2462577 + 777 WP_050956485.1 iron export ABC transporter permease subunit FetB -
KU513_RS12325 (2462973) 2462973..2464160 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T208341 WP_000074048.1 NZ_CP077872:2459202-2459468 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T208341 NZ_CP103623:c2486885-2486709 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT208341 WP_000587616.1 NZ_CP077872:2458945-2459202 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208341 NZ_CP103623:c2486663-2486247 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References