Detailed information of TA system TA208337

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1237347..1237654
• Replicon: chromosome
• Accession: NZ_CP077872
• Organism: Staphylococcus aureus strain 358

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU513_RS06215
• Protein ID: WP_011447039.1
• Coordinates: 1237478..1237654 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1237347..1237486 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU513_RS06170 (1232619)	1232619..1233176	-	558	WP_000528632.1	PBECR4 domain-containing protein	-
KU513_RS06175 (1233812)	1233812..1233997	-	186	WP_001286805.1	hypothetical protein	-
KU513_RS06180 (1233999)	1233999..1234109	-	111	WP_000139423.1	hypothetical protein	-
KU513_RS06185 (1234180)	1234180..1234332	-	153	WP_001788502.1	hypothetical protein	-
KU513_RS06190 (1234577)	1234577..1234912	-	336	Protein_1190	SH3 domain-containing protein	-
KU513_RS06195 (1235563)	1235563..1236054	-	492	WP_000920038.1	staphylokinase	-
KU513_RS06200 (1236245)	1236245..1237000	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU513_RS06205 (1237012)	1237012..1237266	-	255	WP_000611512.1	phage holin	-
KU513_RS06210 (1237318)	1237318..1237425	+	108	WP_031762631.1	hypothetical protein	-
- (1237347)	1237347..1237486	+	140	NuclAT_0	-	Antitoxin
- (1237347)	1237347..1237486	+	140	NuclAT_0	-	Antitoxin
- (1237347)	1237347..1237486	+	140	NuclAT_0	-	Antitoxin
- (1237347)	1237347..1237486	+	140	NuclAT_0	-	Antitoxin
KU513_RS06215 (1237478)	1237478..1237654	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU513_RS06220 (1237763)	1237763..1238536	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
KU513_RS06225 (1238909)	1238909..1239283	-	375	WP_000340977.1	hypothetical protein	-
KU513_RS06230 (1239339)	1239339..1239626	-	288	WP_001262621.1	hypothetical protein	-
KU513_RS06235 (1239672)	1239672..1239824	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / sea	1232619..1277319	44700

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208337 WP_011447039.1 NZ_CP077872:c1237654-1237478 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208337 NZ_CP103623:1826654-1826905 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT208337 NZ_CP077872:1237347-1237486 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin