Detailed information of TA system TA208335

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 264888..265070
• Replicon: chromosome
• Accession: NZ_CP077872
• Organism: Staphylococcus aureus strain 358

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU513_RS01575
• Protein ID: WP_001801861.1
• Coordinates: 264975..265070 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	264888..264947 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU513_RS01560	264026..264403	+	378	WP_001037045.1	DUF1433 domain-containing protein	-
KU513_RS01565	264597..264773	+	177	Protein_269	transposase	-
KU513_RS01570	264751..264852	-	102	WP_001791893.1	hypothetical protein	-
-	264888..264947	+	60	-	-	Antitoxin
KU513_RS01575	264975..265070	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
KU513_RS01580	265273..265416	+	144	WP_001549059.1	transposase	-
KU513_RS01585	266020..266403	+	384	WP_000070812.1	hypothetical protein	-
KU513_RS01590	266414..266590	+	177	WP_000375476.1	hypothetical protein	-
KU513_RS01595	266592..266777	+	186	WP_000809857.1	hypothetical protein	-
KU513_RS01600	266892..267533	+	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
KU513_RS01605	267751..268302	-	552	WP_000414205.1	hypothetical protein	-
KU513_RS01610	268400..268744	-	345	WP_000627551.1	DUF3969 family protein	-
KU513_RS01615	268785..269411	-	627	WP_000669046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	189342..302538	113196

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208335 WP_001801861.1 NZ_CP077872:c265070-264975 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208335 NZ_CP103623:1008027-1008362 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT208335 NZ_CP077872:264888-264947 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin