208332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2572027..2572550 Replicon chromosome
Accession NZ_CP077870
Organism Staphylococcus aureus strain 360

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag KU523_RS12990 Protein ID WP_000074048.1
Coordinates 2572027..2572293 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KU523_RS12995 Protein ID WP_000587616.1
Coordinates 2572293..2572550 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU523_RS12970 (2567335) 2567335..2568522 - 1188 WP_000026194.1 MFS transporter -
KU523_RS12975 (2568918) 2568918..2569694 - 777 WP_050956485.1 iron export ABC transporter permease subunit FetB -
KU523_RS12980 (2569687) 2569687..2570349 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
KU523_RS12985 (2570596) 2570596..2571672 - 1077 WP_001076671.1 M42 family metallopeptidase -
KU523_RS12990 (2572027) 2572027..2572293 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
KU523_RS12995 (2572293) 2572293..2572550 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU523_RS13000 (2572909) 2572909..2573364 + 456 WP_000732082.1 DUF1307 domain-containing protein -
KU523_RS13005 (2573532) 2573532..2575109 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
KU523_RS13010 (2575304) 2575304..2576053 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
KU523_RS13015 (2576277) 2576277..2577470 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T208332 WP_000074048.1 NZ_CP077870:c2572293-2572027 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T208332 NZ_CP103623:263202-263477 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT208332 WP_000587616.1 NZ_CP077870:c2572550-2572293 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208332 NZ_CP103623:263474-263833 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References