Detailed information of TA system TA208330

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2540530..2540714
• Replicon: chromosome
• Accession: NZ_CP077870
• Organism: Staphylococcus aureus strain 360

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: KU523_RS12850
• Protein ID: WP_000482650.1
• Coordinates: 2540607..2540714 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2540530..2540590 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU523_RS12835	2536060..2536227	-	168	WP_001790576.1	hypothetical protein	-
KU523_RS12840	2536458..2538191	-	1734	WP_031833708.1	ABC transporter ATP-binding protein	-
KU523_RS12845	2538216..2539979	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2540530..2540590	+	61	-	-	Antitoxin
KU523_RS12850	2540607..2540714	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
KU523_RS12855	2540847..2541233	-	387	WP_000779358.1	flippase GtxA	-
KU523_RS12860	2541501..2542643	+	1143	WP_001176863.1	glycerate kinase	-
KU523_RS12865	2542703..2543362	+	660	WP_000831298.1	membrane protein	-
KU523_RS12870	2543544..2544755	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU523_RS12875	2544878..2545351	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208330 WP_000482650.1 NZ_CP077870:c2540714-2540607 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208330 NZ_CP103621:c5138054-5137671 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208330 NZ_CP077870:2540530-2540590 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin