Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2515301..2515818 | Replicon | chromosome |
| Accession | NZ_CP077870 | ||
| Organism | Staphylococcus aureus strain 360 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | KU523_RS12715 | Protein ID | WP_000113262.1 |
| Coordinates | 2515301..2515567 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KU523_RS12720 | Protein ID | WP_000584499.1 |
| Coordinates | 2515567..2515818 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU523_RS12685 (2510727) | 2510727..2511263 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| KU523_RS12690 (2511496) | 2511496..2512320 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| KU523_RS12695 (2512537) | 2512537..2512719 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| KU523_RS12700 (2512803) | 2512803..2513270 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| KU523_RS12705 (2513456) | 2513456..2515006 | - | 1551 | WP_000727762.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KU523_RS12710 (2515195) | 2515195..2515266 | - | 72 | Protein_2464 | hypothetical protein | - |
| KU523_RS12715 (2515301) | 2515301..2515567 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| KU523_RS12720 (2515567) | 2515567..2515818 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KU523_RS12725 (2515983) | 2515983..2516084 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| KU523_RS12730 (2516091) | 2516091..2516690 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| KU523_RS12735 (2516709) | 2516709..2517071 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KU523_RS12740 (2517326) | 2517326..2518576 | + | 1251 | WP_225806110.1 | FemA/FemB family glycyltransferase FmhA | - |
| KU523_RS12745 (2518673) | 2518673..2519404 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KU523_RS12750 (2519401) | 2519401..2520120 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T208329 WP_000113262.1 NZ_CP077870:c2515567-2515301 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T208329 NZ_CP103621:c4661995-4661711 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT208329 WP_000584499.1 NZ_CP077870:c2515818-2515567 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT208329 NZ_CP103621:c4662227-4661985 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGACGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGACGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|