Detailed information of TA system TA208328

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2250268..2250485
• Replicon: chromosome
• Accession: NZ_CP077870
• Organism: Staphylococcus aureus strain 360

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU523_RS11330
• Protein ID: WP_001802298.1
• Coordinates: 2250381..2250485 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2250268..2250323 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU523_RS11305	2246405..2247070	-	666	WP_001024094.1	SDR family oxidoreductase	-
KU523_RS11310	2247222..2247542	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU523_RS11315	2247544..2248524	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU523_RS11320	2248790..2249881	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2250268..2250323	+	56	-	-	Antitoxin
KU523_RS11330	2250381..2250485	-	105	WP_001802298.1	hypothetical protein	Toxin
KU523_RS11335	2250646..2251129	-	484	Protein_2197	recombinase family protein	-
KU523_RS11340	2251172..2252308	-	1137	WP_000115562.1	SAP domain-containing protein	-
KU523_RS11345	2252597..2252689	+	93	WP_001790138.1	hypothetical protein	-
KU523_RS11350	2252978..2253162	+	185	Protein_2200	exotoxin	-
KU523_RS11355	2253394..2254251	-	858	WP_000370924.1	HAD family hydrolase	-
KU523_RS11360	2254319..2255101	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208328 WP_001802298.1 NZ_CP077870:c2250485-2250381 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208328 NZ_CP103621:c4559433-4558900 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGATTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208328 NZ_CP077870:2250268-2250323 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin