Detailed information of TA system TA208323

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1910552..1910734
• Replicon: chromosome
• Accession: NZ_CP077870
• Organism: Staphylococcus aureus strain 360

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU523_RS09375
• Protein ID: WP_001801861.1
• Coordinates: 1910552..1910647 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1910675..1910734 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU523_RS09335	1906211..1906837	+	627	WP_000669046.1	hypothetical protein	-
KU523_RS09340	1906878..1907222	+	345	WP_000627551.1	DUF3969 family protein	-
KU523_RS09345	1907320..1907871	+	552	WP_000414205.1	hypothetical protein	-
KU523_RS09350	1908089..1908730	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
KU523_RS09355	1908845..1909030	-	186	WP_000809857.1	hypothetical protein	-
KU523_RS09360	1909032..1909208	-	177	WP_000375476.1	hypothetical protein	-
KU523_RS09365	1909219..1909602	-	384	WP_000070812.1	hypothetical protein	-
KU523_RS09370	1910206..1910349	-	144	WP_001549059.1	transposase	-
KU523_RS09375	1910552..1910647	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1910675..1910734	-	60	-	-	Antitoxin
KU523_RS09380	1910770..1910871	+	102	WP_001791893.1	hypothetical protein	-
KU523_RS09385	1910849..1911025	-	177	Protein_1849	transposase	-
KU523_RS09390	1911219..1911596	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1903651..1986280	82629

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208323 WP_001801861.1 NZ_CP077870:1910552-1910647 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208323 NZ_CP103621:806781-807191 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT208323 NZ_CP077870:c1910734-1910675 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin