Detailed information of TA system TA208320

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 937969..938307
• Replicon: chromosome
• Accession: NZ_CP077870
• Organism: Staphylococcus aureus strain 360

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU523_RS04735
• Protein ID: WP_011447039.1
• Coordinates: 937969..938145 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	938133..938307 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU523_RS04715	935799..935951	+	153	WP_001000058.1	hypothetical protein	-
KU523_RS04720	935997..936284	+	288	WP_001262621.1	hypothetical protein	-
KU523_RS04725	936340..936714	+	375	WP_000340977.1	hypothetical protein	-
KU523_RS04730	937087..937860	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
KU523_RS04735	937969..938145	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	938133..938307	-	175	-	-	Antitoxin
KU523_RS04745	938357..938611	+	255	WP_000611512.1	phage holin	-
KU523_RS04750	938623..939378	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU523_RS04755	939569..940060	+	492	WP_000920038.1	staphylokinase	-
KU523_RS04760	940711..941046	+	336	Protein_928	SH3 domain-containing protein	-
KU523_RS04765	941291..941443	+	153	WP_001788502.1	hypothetical protein	-
KU523_RS04770	941514..941624	+	111	WP_000139423.1	hypothetical protein	-
KU523_RS04775	941626..941811	+	186	WP_001286805.1	hypothetical protein	-
KU523_RS04780	942447..943004	+	558	WP_000528632.1	PBECR4 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208320 WP_011447039.1 NZ_CP077870:937969-938145 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208320 NZ_CP103619:173757-174248 [Klebsiella pneumoniae]
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT208320 NZ_CP077870:c938307-938133 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin