Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2190549..2191066 | Replicon | chromosome |
| Accession | NZ_CP077869 | ||
| Organism | Staphylococcus aureus strain 365 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | KU517_RS11015 | Protein ID | WP_000113263.1 |
| Coordinates | 2190549..2190815 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KU517_RS11020 | Protein ID | WP_000584499.1 |
| Coordinates | 2190815..2191066 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU517_RS10985 (2185809) | 2185809..2186345 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
| KU517_RS10990 (2186758) | 2186758..2187582 | - | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| KU517_RS10995 (2187786) | 2187786..2187968 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| KU517_RS11000 (2188055) | 2188055..2188522 | - | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
| KU517_RS11005 (2188708) | 2188708..2190255 | - | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KU517_RS11010 (2190443) | 2190443..2190514 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| KU517_RS11015 (2190549) | 2190549..2190815 | - | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| KU517_RS11020 (2190815) | 2190815..2191066 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KU517_RS11025 (2191238) | 2191238..2191329 | - | 92 | Protein_2125 | hypothetical protein | - |
| KU517_RS11030 (2191336) | 2191336..2191935 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| KU517_RS11035 (2191954) | 2191954..2192316 | - | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
| KU517_RS11040 (2192571) | 2192571..2193821 | + | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
| KU517_RS11045 (2193918) | 2193918..2194649 | - | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
| KU517_RS11050 (2194646) | 2194646..2195365 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T208316 WP_000113263.1 NZ_CP077869:c2190815-2190549 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T208316 NZ_CP103618:c4864481-4864197 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT208316 WP_000584499.1 NZ_CP077869:c2191066-2190815 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT208316 NZ_CP103618:c4864713-4864471 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|