Detailed information of TA system TA208314

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1929047..1929264
• Replicon: chromosome
• Accession: NZ_CP077869
• Organism: Staphylococcus aureus strain 365

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU517_RS09665
• Protein ID: WP_001802298.1
• Coordinates: 1929160..1929264 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1929047..1929102 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU517_RS09640	1925238..1925903	-	666	WP_001024088.1	SDR family oxidoreductase	-
KU517_RS09645	1926055..1926375	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU517_RS09650	1926377..1927354	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
KU517_RS09655	1927620..1928711	+	1092	WP_000495695.1	hypothetical protein	-
-	1929047..1929102	+	56	-	-	Antitoxin
KU517_RS09665	1929160..1929264	-	105	WP_001802298.1	hypothetical protein	Toxin
KU517_RS09670	1929425..1929908	-	484	Protein_1863	recombinase family protein	-
KU517_RS09675	1929951..1931087	-	1137	Protein_1864	SAP domain-containing protein	-
KU517_RS09680	1931376..1931468	+	93	WP_031844941.1	hypothetical protein	-
KU517_RS09685	1931755..1931969	+	215	Protein_1866	exotoxin	-
KU517_RS09690	1932163..1933020	-	858	WP_225805762.1	HAD family hydrolase	-
KU517_RS09695	1933088..1933870	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208314 WP_001802298.1 NZ_CP077869:c1929264-1929160 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208314 NZ_CP103618:c4736987-4736454 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208314 NZ_CP077869:1929047-1929102 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin