Detailed information of TA system TA208308

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1404072..1404379
• Replicon: chromosome
• Accession: NZ_CP077869
• Organism: Staphylococcus aureus strain 365

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU517_RS06855
• Protein ID: WP_011447039.1
• Coordinates: 1404203..1404379 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1404072..1404211 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU517_RS06815 (1399640)	1399640..1399819	+	180	WP_000669791.1	hypothetical protein	-
KU517_RS06820 (1400130)	1400130..1400390	+	261	WP_001791826.1	hypothetical protein	-
KU517_RS06825 (1400443)	1400443..1400793	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU517_RS06830 (1401303)	1401303..1401638	-	336	Protein_1340	SH3 domain-containing protein	-
KU517_RS06835 (1402288)	1402288..1402779	-	492	WP_000919350.1	staphylokinase	-
KU517_RS06840 (1402970)	1402970..1403725	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU517_RS06845 (1403737)	1403737..1403991	-	255	WP_000611512.1	phage holin	-
KU517_RS06850 (1404043)	1404043..1404150	+	108	WP_001791821.1	hypothetical protein	-
- (1404072)	1404072..1404211	+	140	NuclAT_0	-	Antitoxin
- (1404072)	1404072..1404211	+	140	NuclAT_0	-	Antitoxin
- (1404072)	1404072..1404211	+	140	NuclAT_0	-	Antitoxin
- (1404072)	1404072..1404211	+	140	NuclAT_0	-	Antitoxin
KU517_RS06855 (1404203)	1404203..1404379	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU517_RS06860 (1404529)	1404529..1404825	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU517_RS06865 (1404883)	1404883..1405170	-	288	WP_094659775.1	hypothetical protein	-
KU517_RS06870 (1405217)	1405217..1405369	-	153	WP_001153681.1	hypothetical protein	-
KU517_RS06875 (1405359)	1405359..1409144	-	3786	WP_000582158.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak	1384242..1444474	60232

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208308 WP_011447039.1 NZ_CP077869:c1404379-1404203 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208308 NZ_CP103618:692928-693269 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT208308 NZ_CP077869:1404072-1404211 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin