Detailed information of TA system TA208301

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1311555..1311893
• Replicon: chromosome
• Accession: NZ_CP077868
• Organism: Staphylococcus aureus strain 366

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU506_RS06535
• Protein ID: WP_011447039.1
• Coordinates: 1311555..1311731 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1311719..1311893 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU506_RS06515	1306790..1310575	+	3786	WP_000582158.1	phage tail spike protein	-
KU506_RS06520	1310565..1310717	+	153	WP_001153681.1	hypothetical protein	-
KU506_RS06525	1310764..1311051	+	288	WP_094659775.1	hypothetical protein	-
KU506_RS06530	1311109..1311405	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU506_RS06535	1311555..1311731	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1311719..1311893	-	175	-	-	Antitoxin
KU506_RS06545	1311943..1312197	+	255	WP_000611512.1	phage holin	-
KU506_RS06550	1312209..1312964	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU506_RS06555	1313155..1313646	+	492	WP_000919350.1	staphylokinase	-
KU506_RS06560	1314296..1314631	+	336	Protein_1258	SH3 domain-containing protein	-
KU506_RS06565	1315141..1315491	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU506_RS06570	1315544..1315804	-	261	WP_001791826.1	hypothetical protein	-
KU506_RS06575	1316115..1316294	-	180	WP_000669791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1272276..1332723	60447

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208301 WP_011447039.1 NZ_CP077868:1311555-1311731 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208301 NZ_CP103614:4038903-4039121 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT208301 NZ_CP077868:c1311893-1311719 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin