Detailed information of TA system TA208295

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 786886..787165
• Replicon: chromosome
• Accession: NZ_CP077868
• Organism: Staphylococcus aureus strain 366

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU506_RS03740
• Protein ID: WP_001802298.1
• Coordinates: 786886..786990 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	786986..787165 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU506_RS03710	782280..783062	+	783	WP_000908190.1	ABC transporter ATP-binding protein	-
KU506_RS03715	783130..783987	+	858	WP_225805762.1	HAD family hydrolase	-
KU506_RS03720	784181..784395	-	215	Protein_732	exotoxin	-
KU506_RS03725	784682..784774	-	93	WP_031844941.1	hypothetical protein	-
KU506_RS03730	785063..786199	+	1137	Protein_734	SAP domain-containing protein	-
KU506_RS03735	786242..786725	+	484	Protein_735	recombinase family protein	-
KU506_RS03740	786886..786990	+	105	WP_001802298.1	hypothetical protein	Toxin
-	786986..787165	-	180	-	-	Antitoxin
KU506_RS03750	787439..788530	-	1092	WP_000495695.1	hypothetical protein	-
KU506_RS03755	788796..789773	-	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
KU506_RS03760	789775..790095	-	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU506_RS03765	790247..790912	+	666	WP_001024088.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208295 WP_001802298.1 NZ_CP077868:786886-786990 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208295 NZ_CP103614:205804-206289 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT208295 NZ_CP077868:c787165-786986 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin