Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 525083..525600 Replicon chromosome
Accession NZ_CP077868
Organism Staphylococcus aureus strain 366

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag KU506_RS02390 Protein ID WP_000113263.1
Coordinates 525334..525600 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU506_RS02385 Protein ID WP_000584499.1
Coordinates 525083..525334 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU506_RS02355 (520784) 520784..521503 + 720 WP_000479576.1 amino acid ABC transporter permease -
KU506_RS02360 (521500) 521500..522231 + 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
KU506_RS02365 (522328) 522328..523578 - 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
KU506_RS02370 (523833) 523833..524195 + 363 WP_000819839.1 DUF4467 domain-containing protein -
KU506_RS02375 (524214) 524214..524813 + 600 WP_000162810.1 DsbA family protein -
KU506_RS02380 (524820) 524820..524911 + 92 Protein_473 hypothetical protein -
KU506_RS02385 (525083) 525083..525334 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU506_RS02390 (525334) 525334..525600 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
KU506_RS02395 (525635) 525635..525706 + 72 WP_223200558.1 hypothetical protein -
KU506_RS02400 (525894) 525894..527441 + 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU506_RS02405 (527627) 527627..528094 + 468 WP_000153338.1 SRPBCC domain-containing protein -
KU506_RS02410 (528181) 528181..528363 + 183 WP_000079140.1 hypothetical protein -
KU506_RS02415 (528567) 528567..529391 + 825 WP_000594633.1 formate/nitrite transporter family protein -
KU506_RS02420 (529804) 529804..530340 + 537 WP_000185901.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T208293 WP_000113263.1 NZ_CP077868:525334-525600 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208293 NZ_CP103612:48354-48491 [Enterobacter cloacae]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCGGTGCTGGTGACGAA
CAATGTGAGAGAGTTTGAGCGGGTACCGGGCCTGGTGCTGGAAAACTGGGTTAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208293 WP_000584499.1 NZ_CP077868:525083-525334 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208293 NZ_CP103612:48127-48357 [Enterobacter cloacae]
ATGCGCACAGTTTCTATTTTTAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTCAG
CGAGCTGGAGATTGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTCG
AAAAAGCCGAACCGGATTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References