Detailed information of TA system TA208291

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 500146..500330
• Replicon: chromosome
• Accession: NZ_CP077868
• Organism: Staphylococcus aureus strain 366

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU506_RS02255
• Protein ID: WP_000482647.1
• Coordinates: 500146..500253 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	500270..500330 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU506_RS02230	495508..495981	+	474	WP_000456483.1	GyrI-like domain-containing protein	-
KU506_RS02235	496104..497315	-	1212	WP_001191921.1	multidrug effflux MFS transporter	-
KU506_RS02240	497498..498157	-	660	WP_000831298.1	membrane protein	-
KU506_RS02245	498217..499359	-	1143	WP_001176863.1	glycerate kinase	-
KU506_RS02250	499627..500013	+	387	WP_000779353.1	flippase GtxA	-
KU506_RS02255	500146..500253	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	500270..500330	-	61	-	-	Antitoxin
KU506_RS02260	500901..502664	+	1764	WP_225805770.1	ABC transporter ATP-binding protein	-
KU506_RS02265	502689..504422	+	1734	WP_000488493.1	ABC transporter ATP-binding protein	-
KU506_RS02270	504653..504820	+	168	WP_031845053.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208291 WP_000482647.1 NZ_CP077868:500146-500253 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208291 NZ_CP103611:c4001694-4001281 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACGCCGCTGTGGCTGTTGTTGCTGTCGTTCGTCGTTTTTGACAGCG
TGCGCAGCCAGCGCCGGATCAATGCCCGCCAGGGTGAGATCAAATTACTGATGGACTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAGTTCCGGCATGATGCTACGGTTACGCCAGGTGGGCGGCGGTAAGTG
CCAGCATCTGTGGCTGGCCGCCGACAGTATGGATATTTCGGAGTGGCGGGAACTGCGCCGGATGCTACTGCAGCAGCAAC
CGACGCAGGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208291 NZ_CP077868:c500330-500270 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin