Detailed information of TA system TA208284

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2272513..2272776
• Replicon: chromosome
• Accession: NZ_CP077867
• Organism: Staphylococcus aureus strain 367

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU500_RS10970
• Protein ID: WP_001802298.1
• Coordinates: 2272513..2272617 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2272612..2272776 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU500_RS10940	2267907..2268689	+	783	WP_000908190.1	ABC transporter ATP-binding protein	-
KU500_RS10945	2268757..2269614	+	858	WP_225805762.1	HAD family hydrolase	-
KU500_RS10950	2269808..2270022	-	215	Protein_2156	exotoxin	-
KU500_RS10955	2270309..2270401	-	93	WP_031844941.1	hypothetical protein	-
KU500_RS10960	2270690..2271826	+	1137	Protein_2158	SAP domain-containing protein	-
KU500_RS10965	2271869..2272352	+	484	Protein_2159	recombinase family protein	-
KU500_RS10970	2272513..2272617	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2272612..2272776	-	165	-	-	Antitoxin
KU500_RS10980	2273066..2274157	-	1092	WP_000495695.1	hypothetical protein	-
KU500_RS10985	2274423..2275400	-	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
KU500_RS10990	2275402..2275722	-	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU500_RS10995	2275874..2276539	+	666	WP_001024088.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208284 WP_001802298.1 NZ_CP077867:2272513-2272617 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208284 NZ_CP103611:178943-179128 [Enterobacter cloacae]
GTGAAAAGTGCGGATGTCATTACTGTTCTGGTCAGGCATGGCTGGAAATGTGTAAGAACGAAAGGAAGCCATCATCAGTT
TCGCCACCCAGTACATGCGGGGTTGGTGACCGTTCCACATCCCAAAAAGGACATAAAACCCGGTACCCTCGCGCAAATCT
GGCGGCAGGCGGGAATCAAACACTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT208284 NZ_CP077867:c2272776-2272612 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin