Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2010711..2011228 | Replicon | chromosome |
| Accession | NZ_CP077867 | ||
| Organism | Staphylococcus aureus strain 367 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | KU500_RS09620 | Protein ID | WP_000113263.1 |
| Coordinates | 2010962..2011228 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KU500_RS09615 | Protein ID | WP_000584499.1 |
| Coordinates | 2010711..2010962 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU500_RS09585 (2006412) | 2006412..2007131 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| KU500_RS09590 (2007128) | 2007128..2007859 | + | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
| KU500_RS09595 (2007956) | 2007956..2009206 | - | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
| KU500_RS09600 (2009461) | 2009461..2009823 | + | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
| KU500_RS09605 (2009842) | 2009842..2010441 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| KU500_RS09610 (2010448) | 2010448..2010539 | + | 92 | Protein_1897 | hypothetical protein | - |
| KU500_RS09615 (2010711) | 2010711..2010962 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KU500_RS09620 (2010962) | 2010962..2011228 | + | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| KU500_RS09625 (2011263) | 2011263..2011334 | + | 72 | WP_223200558.1 | hypothetical protein | - |
| KU500_RS09630 (2011522) | 2011522..2013069 | + | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KU500_RS09635 (2013255) | 2013255..2013722 | + | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
| KU500_RS09640 (2013809) | 2013809..2013991 | + | 183 | WP_000079140.1 | hypothetical protein | - |
| KU500_RS09645 (2014195) | 2014195..2015019 | + | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| KU500_RS09650 (2015432) | 2015432..2015968 | + | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T208283 WP_000113263.1 NZ_CP077867:2010962-2011228 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T208283 NZ_CP103610:c83845-83465 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT208283 WP_000584499.1 NZ_CP077867:2010711-2010962 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT208283 NZ_CP103610:c84066-83845 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTTGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTTGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|