Detailed information of TA system TA208283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2010711..2011228
• Replicon: chromosome
• Accession: NZ_CP077867
• Organism: Staphylococcus aureus strain 367

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: KU500_RS09620
• Protein ID: WP_000113263.1
• Coordinates: 2010962..2011228 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: KU500_RS09615
• Protein ID: WP_000584499.1
• Coordinates: 2010711..2010962 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU500_RS09585 (2006412)	2006412..2007131	+	720	WP_000479576.1	amino acid ABC transporter permease	-
KU500_RS09590 (2007128)	2007128..2007859	+	732	WP_000615464.1	amino acid ABC transporter ATP-binding protein	-
KU500_RS09595 (2007956)	2007956..2009206	-	1251	WP_001012236.1	FemA/FemB family glycyltransferase FmhA	-
KU500_RS09600 (2009461)	2009461..2009823	+	363	WP_000819839.1	DUF4467 domain-containing protein	-
KU500_RS09605 (2009842)	2009842..2010441	+	600	WP_000162810.1	DsbA family protein	-
KU500_RS09610 (2010448)	2010448..2010539	+	92	Protein_1897	hypothetical protein	-
KU500_RS09615 (2010711)	2010711..2010962	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KU500_RS09620 (2010962)	2010962..2011228	+	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
KU500_RS09625 (2011263)	2011263..2011334	+	72	WP_223200558.1	hypothetical protein	-
KU500_RS09630 (2011522)	2011522..2013069	+	1548	WP_000727757.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
KU500_RS09635 (2013255)	2013255..2013722	+	468	WP_000153338.1	SRPBCC domain-containing protein	-
KU500_RS09640 (2013809)	2013809..2013991	+	183	WP_000079140.1	hypothetical protein	-
KU500_RS09645 (2014195)	2014195..2015019	+	825	WP_000594633.1	formate/nitrite transporter family protein	-
KU500_RS09650 (2015432)	2015432..2015968	+	537	WP_000185901.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T208283 WP_000113263.1 NZ_CP077867:2010962-2011228 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T208283 NZ_CP103610:c83845-83465 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT208283 WP_000584499.1 NZ_CP077867:2010711-2010962 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT208283 NZ_CP103610:c84066-83845 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTTGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9

Antitoxin

• AlphaFold DB: T1YB60