Detailed information of TA system TA208281

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1985774..1985958
• Replicon: chromosome
• Accession: NZ_CP077867
• Organism: Staphylococcus aureus strain 367

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU500_RS09480
• Protein ID: WP_000482647.1
• Coordinates: 1985774..1985881 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1985898..1985958 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU500_RS09455	1981136..1981609	+	474	WP_000456483.1	GyrI-like domain-containing protein	-
KU500_RS09460	1981732..1982943	-	1212	WP_001191921.1	multidrug effflux MFS transporter	-
KU500_RS09465	1983126..1983785	-	660	WP_000831298.1	membrane protein	-
KU500_RS09470	1983845..1984987	-	1143	WP_001176863.1	glycerate kinase	-
KU500_RS09475	1985255..1985641	+	387	WP_000779353.1	flippase GtxA	-
KU500_RS09480	1985774..1985881	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1985898..1985958	-	61	-	-	Antitoxin
KU500_RS09485	1985908..1986075	+	168	WP_000301893.1	hypothetical protein	-
KU500_RS09490	1986529..1988292	+	1764	WP_225805770.1	ABC transporter ATP-binding protein	-
KU500_RS09495	1988317..1990050	+	1734	WP_000488493.1	ABC transporter ATP-binding protein	-
KU500_RS09500	1990281..1990448	+	168	WP_031845053.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208281 WP_000482647.1 NZ_CP077867:1985774-1985881 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208281 NZ_CP103609:c4720572-4720465 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208281 NZ_CP077867:c1985958-1985898 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin