Detailed information of TA system TA208276

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 10792..11130
• Replicon: chromosome
• Accession: NZ_CP077867
• Organism: Staphylococcus aureus strain 367

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU500_RS00035
• Protein ID: WP_011447039.1
• Coordinates: 10792..10968 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	10956..11130 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU500_RS00015	6027..9812	+	3786	WP_000582158.1	phage tail spike protein	-
KU500_RS00020	9802..9954	+	153	WP_001153681.1	hypothetical protein	-
KU500_RS00025	10001..10288	+	288	WP_094659775.1	hypothetical protein	-
KU500_RS00030	10346..10642	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU500_RS00035	10792..10968	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	10956..11130	-	175	-	-	Antitoxin
KU500_RS00045	11180..11434	+	255	WP_000611512.1	phage holin	-
KU500_RS00050	11446..12201	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU500_RS00055	12392..12883	+	492	WP_000919350.1	staphylokinase	-
KU500_RS00060	13533..13868	+	336	Protein_11	SH3 domain-containing protein	-
KU500_RS00065	14378..14728	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU500_RS00070	14781..15041	-	261	WP_001791826.1	hypothetical protein	-
KU500_RS00075	15352..15531	-	180	WP_000669791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1..31960	31959

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208276 WP_011447039.1 NZ_CP077867:10792-10968 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208276 NZ_CP103609:c3874291-3873956 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT208276 NZ_CP077867:c11130-10956 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin