Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1057516..1057700 Replicon chromosome
Accession NZ_CP077865
Organism Staphylococcus aureus strain 370

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag KU528_RS05440 Protein ID WP_000482647.1
Coordinates 1057593..1057700 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1057516..1057576 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU528_RS05420 1053026..1053193 - 168 WP_031845053.1 hypothetical protein -
KU528_RS05425 1053424..1055157 - 1734 WP_000488493.1 ABC transporter ATP-binding protein -
KU528_RS05430 1055182..1056945 - 1764 WP_225805770.1 ABC transporter ATP-binding protein -
KU528_RS05435 1057399..1057566 - 168 WP_000301893.1 hypothetical protein -
- 1057516..1057576 + 61 - - Antitoxin
KU528_RS05440 1057593..1057700 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
KU528_RS05445 1057833..1058219 - 387 WP_000779353.1 flippase GtxA -
KU528_RS05450 1058487..1059629 + 1143 WP_001176863.1 glycerate kinase -
KU528_RS05455 1059689..1060348 + 660 WP_000831298.1 membrane protein -
KU528_RS05460 1060531..1061742 + 1212 WP_001191921.1 multidrug effflux MFS transporter -
KU528_RS05465 1061865..1062338 - 474 WP_000456483.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T208272 WP_000482647.1 NZ_CP077865:c1057700-1057593 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208272 NZ_CP103609:c2837992-2837889 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT208272 NZ_CP077865:1057516-1057576 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References