Detailed information of TA system TA208269

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 770743..770960
• Replicon: chromosome
• Accession: NZ_CP077865
• Organism: Staphylococcus aureus strain 370

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU528_RS03950
• Protein ID: WP_001802298.1
• Coordinates: 770856..770960 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	770743..770798 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU528_RS03925	766934..767599	-	666	WP_001024088.1	SDR family oxidoreductase	-
KU528_RS03930	767751..768071	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU528_RS03935	768073..769050	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
KU528_RS03940	769316..770407	+	1092	WP_000495695.1	hypothetical protein	-
-	770743..770798	+	56	-	-	Antitoxin
KU528_RS03950	770856..770960	-	105	WP_001802298.1	hypothetical protein	Toxin
KU528_RS03955	771121..771604	-	484	Protein_744	recombinase family protein	-
KU528_RS03960	771647..772783	-	1137	Protein_745	SAP domain-containing protein	-
KU528_RS03965	773072..773164	+	93	WP_031844941.1	hypothetical protein	-
KU528_RS03970	773451..773665	+	215	Protein_747	exotoxin	-
KU528_RS03975	773859..774716	-	858	WP_225805762.1	HAD family hydrolase	-
KU528_RS03980	774784..775566	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208269 WP_001802298.1 NZ_CP077865:c770960-770856 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208269 NZ_CP103609:c2205370-2205263 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208269 NZ_CP077865:770743-770798 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin