Detailed information of TA system TA208263

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 245769..246076
• Replicon: chromosome
• Accession: NZ_CP077865
• Organism: Staphylococcus aureus strain 370

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU528_RS01140
• Protein ID: WP_011447039.1
• Coordinates: 245900..246076 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	245769..245908 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU528_RS01100 (241337)	241337..241516	+	180	WP_000669791.1	hypothetical protein	-
KU528_RS01105 (241827)	241827..242087	+	261	WP_001791826.1	hypothetical protein	-
KU528_RS01110 (242140)	242140..242490	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU528_RS01115 (243000)	243000..243335	-	336	Protein_221	SH3 domain-containing protein	-
KU528_RS01120 (243985)	243985..244476	-	492	WP_000919350.1	staphylokinase	-
KU528_RS01125 (244667)	244667..245422	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU528_RS01130 (245434)	245434..245688	-	255	WP_000611512.1	phage holin	-
KU528_RS01135 (245740)	245740..245847	+	108	WP_001791821.1	hypothetical protein	-
- (245769)	245769..245908	+	140	NuclAT_0	-	Antitoxin
- (245769)	245769..245908	+	140	NuclAT_0	-	Antitoxin
- (245769)	245769..245908	+	140	NuclAT_0	-	Antitoxin
- (245769)	245769..245908	+	140	NuclAT_0	-	Antitoxin
KU528_RS01140 (245900)	245900..246076	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU528_RS01145 (246226)	246226..246522	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU528_RS01150 (246580)	246580..246867	-	288	WP_094659775.1	hypothetical protein	-
KU528_RS01155 (246914)	246914..247066	-	153	WP_001153681.1	hypothetical protein	-
KU528_RS01160 (247056)	247056..250841	-	3786	WP_000582158.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak	235403..285355	49952

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208263 WP_011447039.1 NZ_CP077865:c246076-245900 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208263 NZ_CP103609:672696-673046 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT208263 NZ_CP077865:245769-245908 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin