Detailed information of TA system TA208260

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2640583..2640921
• Replicon: chromosome
• Accession: NZ_CP077863
• Organism: Staphylococcus aureus strain 371

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU524_RS12910
• Protein ID: WP_011447039.1
• Coordinates: 2640583..2640759 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2640747..2640921 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU524_RS12890	2635818..2639603	+	3786	WP_000582158.1	phage tail spike protein	-
KU524_RS12895	2639593..2639745	+	153	WP_001153681.1	hypothetical protein	-
KU524_RS12900	2639792..2640079	+	288	WP_094659775.1	hypothetical protein	-
KU524_RS12905	2640137..2640433	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU524_RS12910	2640583..2640759	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2640747..2640921	-	175	-	-	Antitoxin
KU524_RS12920	2640971..2641225	+	255	WP_000611512.1	phage holin	-
KU524_RS12925	2641237..2641992	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU524_RS12930	2642183..2642674	+	492	WP_000919350.1	staphylokinase	-
KU524_RS12935	2643324..2643659	+	336	Protein_2507	SH3 domain-containing protein	-
KU524_RS12940	2644169..2644519	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU524_RS12945	2644572..2644832	-	261	WP_001791826.1	hypothetical protein	-
KU524_RS12950	2645143..2645322	-	180	WP_000669791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	2601304..2661751	60447

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208260 WP_011447039.1 NZ_CP077863:2640583-2640759 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208260 NZ_CP103609:31448-31825 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT208260 NZ_CP077863:c2640921-2640747 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin