Detailed information of TA system TA208254

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2115812..2116091
• Replicon: chromosome
• Accession: NZ_CP077863
• Organism: Staphylococcus aureus strain 371

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU524_RS10100
• Protein ID: WP_001802298.1
• Coordinates: 2115812..2115916 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2115912..2116091 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU524_RS10070	2111206..2111988	+	783	WP_000908190.1	ABC transporter ATP-binding protein	-
KU524_RS10075	2112056..2112913	+	858	WP_225805762.1	HAD family hydrolase	-
KU524_RS10080	2113107..2113321	-	215	Protein_1981	exotoxin	-
KU524_RS10085	2113608..2113700	-	93	WP_031844941.1	hypothetical protein	-
KU524_RS10090	2113989..2115125	+	1137	Protein_1983	SAP domain-containing protein	-
KU524_RS10095	2115168..2115651	+	484	Protein_1984	recombinase family protein	-
KU524_RS10100	2115812..2115916	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2115912..2116091	-	180	-	-	Antitoxin
KU524_RS10110	2116365..2117456	-	1092	WP_000495695.1	hypothetical protein	-
KU524_RS10115	2117722..2118699	-	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
KU524_RS10120	2118701..2119021	-	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU524_RS10125	2119173..2119838	+	666	WP_001024088.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208254 WP_001802298.1 NZ_CP077863:2115812-2115916 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208254 NZ_CP103605:3948275-3948493 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT208254 NZ_CP077863:c2116091-2115912 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin