Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1854010..1854527 Replicon chromosome
Accession NZ_CP077863
Organism Staphylococcus aureus strain 371

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag KU524_RS08750 Protein ID WP_000113263.1
Coordinates 1854261..1854527 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU524_RS08745 Protein ID WP_000584499.1
Coordinates 1854010..1854261 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU524_RS08715 (1849711) 1849711..1850430 + 720 WP_000479576.1 amino acid ABC transporter permease -
KU524_RS08720 (1850427) 1850427..1851158 + 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
KU524_RS08725 (1851255) 1851255..1852505 - 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
KU524_RS08730 (1852760) 1852760..1853122 + 363 WP_000819839.1 DUF4467 domain-containing protein -
KU524_RS08735 (1853141) 1853141..1853740 + 600 WP_000162810.1 DsbA family protein -
KU524_RS08740 (1853747) 1853747..1853838 + 92 Protein_1722 hypothetical protein -
KU524_RS08745 (1854010) 1854010..1854261 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU524_RS08750 (1854261) 1854261..1854527 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
KU524_RS08755 (1854562) 1854562..1854633 + 72 WP_223200558.1 hypothetical protein -
KU524_RS08760 (1854821) 1854821..1856368 + 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU524_RS08765 (1856554) 1856554..1857021 + 468 WP_000153338.1 SRPBCC domain-containing protein -
KU524_RS08770 (1857108) 1857108..1857290 + 183 WP_000079140.1 hypothetical protein -
KU524_RS08775 (1857494) 1857494..1858318 + 825 WP_000594633.1 formate/nitrite transporter family protein -
KU524_RS08780 (1858731) 1858731..1859267 + 537 WP_000185901.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T208252 WP_000113263.1 NZ_CP077863:1854261-1854527 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208252 NZ_CP103605:1911758-1911860 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208252 WP_000584499.1 NZ_CP077863:1854010-1854261 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208252 NZ_CP103605:c1911867-1911722 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References