Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1829073..1829257 Replicon chromosome
Accession NZ_CP077863
Organism Staphylococcus aureus strain 371

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag KU524_RS08610 Protein ID WP_000482647.1
Coordinates 1829073..1829180 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1829197..1829257 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU524_RS08585 1824435..1824908 + 474 WP_000456483.1 GyrI-like domain-containing protein -
KU524_RS08590 1825031..1826242 - 1212 WP_001191921.1 multidrug effflux MFS transporter -
KU524_RS08595 1826425..1827084 - 660 WP_000831298.1 membrane protein -
KU524_RS08600 1827144..1828286 - 1143 WP_001176863.1 glycerate kinase -
KU524_RS08605 1828554..1828940 + 387 WP_000779353.1 flippase GtxA -
KU524_RS08610 1829073..1829180 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1829197..1829257 - 61 - - Antitoxin
KU524_RS08615 1829207..1829374 + 168 WP_000301893.1 hypothetical protein -
KU524_RS08620 1829828..1831591 + 1764 WP_225805770.1 ABC transporter ATP-binding protein -
KU524_RS08625 1831616..1833349 + 1734 WP_000488493.1 ABC transporter ATP-binding protein -
KU524_RS08630 1833580..1833747 + 168 WP_031845053.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T208250 WP_000482647.1 NZ_CP077863:1829073-1829180 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208250 NZ_CP103605:740937-741422 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin


Download         Length: 61 bp

>AT208250 NZ_CP077863:c1829257-1829197 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7


Antitoxin

Download structure file

References