Detailed information of TA system TA208244

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1040295..1040479
• Replicon: chromosome
• Accession: NZ_CP077861
• Organism: Staphylococcus aureus strain 372

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU510_RS05345
• Protein ID: WP_000482647.1
• Coordinates: 1040372..1040479 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1040295..1040355 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU510_RS05330	1035805..1035972	-	168	WP_031845053.1	hypothetical protein	-
KU510_RS05335	1036203..1037936	-	1734	WP_000488493.1	ABC transporter ATP-binding protein	-
KU510_RS05340	1037961..1039724	-	1764	WP_225805770.1	ABC transporter ATP-binding protein	-
-	1040295..1040355	+	61	-	-	Antitoxin
KU510_RS05345	1040372..1040479	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
KU510_RS05350	1040612..1040998	-	387	WP_000779353.1	flippase GtxA	-
KU510_RS05355	1041266..1042408	+	1143	WP_001176863.1	glycerate kinase	-
KU510_RS05360	1042468..1043127	+	660	WP_000831298.1	membrane protein	-
KU510_RS05365	1043310..1044521	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
KU510_RS05370	1044644..1045117	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208244 WP_000482647.1 NZ_CP077861:c1040479-1040372 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208244 NZ_CP103597:c51245-50967 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT208244 NZ_CP077861:1040295-1040355 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin