Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 1015025..1015542 | Replicon | chromosome |
| Accession | NZ_CP077861 | ||
| Organism | Staphylococcus aureus strain 372 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | KU510_RS05210 | Protein ID | WP_000113263.1 |
| Coordinates | 1015025..1015291 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KU510_RS05215 | Protein ID | WP_000584499.1 |
| Coordinates | 1015291..1015542 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU510_RS05180 (1010285) | 1010285..1010821 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
| KU510_RS05185 (1011234) | 1011234..1012058 | - | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| KU510_RS05190 (1012262) | 1012262..1012444 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| KU510_RS05195 (1012531) | 1012531..1012998 | - | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
| KU510_RS05200 (1013184) | 1013184..1014731 | - | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KU510_RS05205 (1014919) | 1014919..1014990 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| KU510_RS05210 (1015025) | 1015025..1015291 | - | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| KU510_RS05215 (1015291) | 1015291..1015542 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KU510_RS05220 (1015714) | 1015714..1015805 | - | 92 | Protein_989 | hypothetical protein | - |
| KU510_RS05225 (1015812) | 1015812..1016411 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| KU510_RS05230 (1016430) | 1016430..1016792 | - | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
| KU510_RS05235 (1017047) | 1017047..1018297 | + | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
| KU510_RS05240 (1018394) | 1018394..1019125 | - | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
| KU510_RS05245 (1019122) | 1019122..1019841 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T208243 WP_000113263.1 NZ_CP077861:c1015291-1015025 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T208243 NZ_CP103596:c4250892-4250719 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT208243 WP_000584499.1 NZ_CP077861:c1015542-1015291 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT208243 NZ_CP103596:c4251216-4250920 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|