208243

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1015025..1015542 Replicon chromosome
Accession NZ_CP077861
Organism Staphylococcus aureus strain 372

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag KU510_RS05210 Protein ID WP_000113263.1
Coordinates 1015025..1015291 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU510_RS05215 Protein ID WP_000584499.1
Coordinates 1015291..1015542 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU510_RS05180 (1010285) 1010285..1010821 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
KU510_RS05185 (1011234) 1011234..1012058 - 825 WP_000594633.1 formate/nitrite transporter family protein -
KU510_RS05190 (1012262) 1012262..1012444 - 183 WP_000079140.1 hypothetical protein -
KU510_RS05195 (1012531) 1012531..1012998 - 468 WP_000153338.1 SRPBCC domain-containing protein -
KU510_RS05200 (1013184) 1013184..1014731 - 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU510_RS05205 (1014919) 1014919..1014990 - 72 WP_223200558.1 hypothetical protein -
KU510_RS05210 (1015025) 1015025..1015291 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
KU510_RS05215 (1015291) 1015291..1015542 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU510_RS05220 (1015714) 1015714..1015805 - 92 Protein_989 hypothetical protein -
KU510_RS05225 (1015812) 1015812..1016411 - 600 WP_000162810.1 DsbA family protein -
KU510_RS05230 (1016430) 1016430..1016792 - 363 WP_000819839.1 DUF4467 domain-containing protein -
KU510_RS05235 (1017047) 1017047..1018297 + 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
KU510_RS05240 (1018394) 1018394..1019125 - 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
KU510_RS05245 (1019122) 1019122..1019841 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T208243 WP_000113263.1 NZ_CP077861:c1015291-1015025 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208243 NZ_CP103596:c4250892-4250719 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208243 WP_000584499.1 NZ_CP077861:c1015542-1015291 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208243 NZ_CP103596:c4251216-4250920 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References