Detailed information of TA system TA208241

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 753523..753740
• Replicon: chromosome
• Accession: NZ_CP077861
• Organism: Staphylococcus aureus strain 372

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU510_RS03860
• Protein ID: WP_001802298.1
• Coordinates: 753636..753740 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	753523..753578 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU510_RS03835	749714..750379	-	666	WP_001024088.1	SDR family oxidoreductase	-
KU510_RS03840	750531..750851	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU510_RS03845	750853..751830	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
KU510_RS03850	752096..753187	+	1092	WP_000495695.1	hypothetical protein	-
-	753523..753578	+	56	-	-	Antitoxin
KU510_RS03860	753636..753740	-	105	WP_001802298.1	hypothetical protein	Toxin
KU510_RS03865	753901..754384	-	484	Protein_727	recombinase family protein	-
KU510_RS03870	754427..755563	-	1137	Protein_728	SAP domain-containing protein	-
KU510_RS03875	755852..755944	+	93	WP_031844941.1	hypothetical protein	-
KU510_RS03880	756231..756445	+	215	Protein_730	exotoxin	-
KU510_RS03885	756639..757496	-	858	WP_225805762.1	HAD family hydrolase	-
KU510_RS03890	757564..758346	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208241 WP_001802298.1 NZ_CP077861:c753740-753636 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208241 NZ_CP103596:c4035019-4034645 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGACTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208241 NZ_CP077861:753523-753578 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin