Detailed information of TA system TA208236

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 228556..228855
• Replicon: chromosome
• Accession: NZ_CP077861
• Organism: Staphylococcus aureus strain 372

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU510_RS01055
• Protein ID: WP_011447039.1
• Coordinates: 228679..228855 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	228556..228611 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU510_RS01015	224116..224295	+	180	WP_000669791.1	hypothetical protein	-
KU510_RS01020	224606..224866	+	261	WP_001791826.1	hypothetical protein	-
KU510_RS01025	224919..225269	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU510_RS01030	225779..226114	-	336	Protein_204	SH3 domain-containing protein	-
KU510_RS01035	226764..227255	-	492	WP_000919350.1	staphylokinase	-
KU510_RS01040	227446..228201	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU510_RS01045	228213..228467	-	255	WP_000611512.1	phage holin	-
KU510_RS01050	228519..228626	+	108	WP_001791821.1	hypothetical protein	-
-	228548..228687	+	140	NuclAT_0	-	-
-	228548..228687	+	140	NuclAT_0	-	-
-	228548..228687	+	140	NuclAT_0	-	-
-	228548..228687	+	140	NuclAT_0	-	-
-	228556..228611	+	56	-	-	Antitoxin
KU510_RS01055	228679..228855	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU510_RS01060	229005..229301	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU510_RS01065	229359..229646	-	288	WP_094659775.1	hypothetical protein	-
KU510_RS01070	229693..229845	-	153	WP_001153681.1	hypothetical protein	-
KU510_RS01075	229835..233620	-	3786	WP_000582158.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak	218182..268134	49952

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208236 WP_011447039.1 NZ_CP077861:c228855-228679 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208236 NZ_CP103596:2685143-2685250 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208236 NZ_CP077861:228556-228611 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin