Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-SprF1/- |
| Location | 228548..228855 | Replicon | chromosome |
| Accession | NZ_CP077861 | ||
| Organism | Staphylococcus aureus strain 372 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | KU510_RS01055 | Protein ID | WP_011447039.1 |
| Coordinates | 228679..228855 (-) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | SprF1 | ||
| Locus tag | - | ||
| Coordinates | 228548..228687 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU510_RS01015 (224116) | 224116..224295 | + | 180 | WP_000669791.1 | hypothetical protein | - |
| KU510_RS01020 (224606) | 224606..224866 | + | 261 | WP_001791826.1 | hypothetical protein | - |
| KU510_RS01025 (224919) | 224919..225269 | - | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
| KU510_RS01030 (225779) | 225779..226114 | - | 336 | Protein_204 | SH3 domain-containing protein | - |
| KU510_RS01035 (226764) | 226764..227255 | - | 492 | WP_000919350.1 | staphylokinase | - |
| KU510_RS01040 (227446) | 227446..228201 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
| KU510_RS01045 (228213) | 228213..228467 | - | 255 | WP_000611512.1 | phage holin | - |
| KU510_RS01050 (228519) | 228519..228626 | + | 108 | WP_001791821.1 | hypothetical protein | - |
| - (228548) | 228548..228687 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (228548) | 228548..228687 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (228548) | 228548..228687 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (228548) | 228548..228687 | + | 140 | NuclAT_0 | - | Antitoxin |
| KU510_RS01055 (228679) | 228679..228855 | - | 177 | WP_011447039.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| KU510_RS01060 (229005) | 229005..229301 | - | 297 | WP_000539688.1 | DUF2951 domain-containing protein | - |
| KU510_RS01065 (229359) | 229359..229646 | - | 288 | WP_094659775.1 | hypothetical protein | - |
| KU510_RS01070 (229693) | 229693..229845 | - | 153 | WP_001153681.1 | hypothetical protein | - |
| KU510_RS01075 (229835) | 229835..233620 | - | 3786 | WP_000582158.1 | phage tail spike protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / sak | 218182..268134 | 49952 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T208235 WP_011447039.1 NZ_CP077861:c228855-228679 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T208235 NZ_CP103596:2684608-2684715 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 140 bp
>AT208235 NZ_CP077861:228548-228687 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
