208231

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1402266..1402450 Replicon chromosome
Accession NZ_CP077860
Organism Staphylococcus aureus strain AC4

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag KU521_RS07130 Protein ID WP_000482652.1
Coordinates 1402343..1402450 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1402266..1402326 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU521_RS07115 1397722..1397853 - 132 WP_223197975.1 hypothetical protein -
KU521_RS07120 1398120..1399853 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
KU521_RS07125 1399878..1401641 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 1402266..1402326 + 61 - - Antitoxin
KU521_RS07130 1402343..1402450 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
KU521_RS07135 1402584..1402970 - 387 WP_000779360.1 flippase GtxA -
KU521_RS07140 1403238..1404380 + 1143 WP_225798608.1 glycerate kinase -
KU521_RS07145 1404440..1405099 + 660 WP_000831298.1 membrane protein -
KU521_RS07150 1405281..1406492 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
KU521_RS07155 1406615..1407088 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T208231 WP_000482652.1 NZ_CP077860:c1402450-1402343 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208231 NZ_CP103596:1969627-1969730 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT208231 NZ_CP077860:1402266-1402326 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References