Detailed information of TA system TA208228

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1117333..1117549
• Replicon: chromosome
• Accession: NZ_CP077860
• Organism: Staphylococcus aureus strain AC4

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU521_RS05650
• Protein ID: WP_001802298.1
• Coordinates: 1117445..1117549 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1117333..1117388 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU521_RS05625	1113539..1114204	-	666	WP_001024095.1	SDR family oxidoreductase	-
KU521_RS05630	1114356..1114676	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU521_RS05635	1114678..1115655	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
KU521_RS05640	1115921..1117012	+	1092	WP_000495669.1	hypothetical protein	-
-	1117333..1117388	+	56	-	-	Antitoxin
KU521_RS05650	1117445..1117549	-	105	WP_001802298.1	hypothetical protein	Toxin
KU521_RS05655	1118229..1118387	+	159	WP_001792784.1	hypothetical protein	-
KU521_RS05660	1119045..1119902	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
KU521_RS05665	1119970..1120752	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208228 WP_001802298.1 NZ_CP077860:c1117549-1117445 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208228 NZ_CP103596:1788872-1789123 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208228 NZ_CP077860:1117333-1117388 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin