Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2487517..2487795 Replicon chromosome
Accession NZ_CP077859
Organism Staphylococcus aureus strain AC5

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag KU537_RS12075 Protein ID WP_001802298.1
Coordinates 2487517..2487621 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2487617..2487795 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU537_RS12060 2484314..2485096 + 783 WP_000908182.1 ABC transporter ATP-binding protein -
KU537_RS12065 2485164..2486021 + 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
KU537_RS12070 2486679..2486837 - 159 WP_001792784.1 hypothetical protein -
KU537_RS12075 2487517..2487621 + 105 WP_001802298.1 hypothetical protein Toxin
- 2487617..2487795 - 179 - - Antitoxin
KU537_RS12085 2488054..2489145 - 1092 WP_000495669.1 hypothetical protein -
KU537_RS12090 2489411..2490388 - 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
KU537_RS12095 2490390..2490710 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
KU537_RS12100 2490862..2491527 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T208210 WP_001802298.1 NZ_CP077859:2487517-2487621 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T208210 NZ_CP103592:2800935-2801042 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 179 bp

>AT208210 NZ_CP077859:c2487795-2487617 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References